Molecular Epidemiology of Blastomyces dermatitidis
نویسندگان
چکیده
منابع مشابه
Molecular epidemiology of Blastomyces dermatitidis.
The inhalation of conidia of Blastomyces dermatitidis, a fungus found in soil, causes disease in humans and animals. We studied the genetic diversity of this pathogen by extracting DNA yeasts and analyzing them with a polymerase chain reaction (PCR)-based typing system we developed, which used restriction fragment analysis of amplicons from the regions between the rDNA repeats and allowed us to...
متن کاملThe unappreciated intracellular lifestyle of Blastomyces dermatitidis.
Blastomyces dermatitidis, a dimorphic fungus and the causative agent of blastomycosis, is widely considered an extracellular pathogen, with little evidence for a facultative intracellular lifestyle. We infected mice with spores, that is, the infectious particle, via the pulmonary route and studied intracellular residence, transition to pathogenic yeast, and replication inside lung cells. Nearly...
متن کاملSevere Oculofacial Sequelae of Cutaneous Blastomyces dermatitidis.
This study reports a case of Blastomyces dermatitidis soft tissue infection resulting in a disfiguring lower eyelid ectropion from cicatricial and postinflammatory cutaneous changes. Primary treatment included intravenous amphotericin B followed by long-term oral itraconazole, which resulted in complete remission of the disease without debridement, after which cicatricial ectropion was repaired...
متن کاملMicroecology of Blastomyces dermatitidis: the ammonia hypothesis.
The precise microecology of Blastomyces dermatitidis is unknown, but the fungus has been associated with nitrogenous waste products and rapidly changing environmental conditions. Ammonia accumulates in certain microenvironments, is toxic to most fungi, but may not be identified in processed soil samples. Ammonia tolerance of B. dermatitidis was investigated with two strains recovered in Wiscons...
متن کاملEnhanced Toxicity in Chemically Altered Blastomyces Dermatitidis.
Several fungi pathogenic for man, including Blastomyces dermatitidis, Histoplasma capsulatum, and Candida albicans, are known to possess endotoxin activity upon injection into experimental animals (Baker, Am. J. Pathol. 16:463, 1942; Salvin, J. Immunol. 69:89, 1952; Box and Briggs, J. Immunol. 87:485, 1961; Mourad and Friedman, J. Bacteriol. 81:550,1961; Hasenclever and Mitchell, J. Bacteriol. ...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2000
ISSN: 1058-4838,1537-6591
DOI: 10.1086/313649